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Wendland NY8478wusa 19-04-2011 10:24:59. Windows.7.Dutch.NL.Retail.32Bit.64bit.all.versions — [Joske] 11.Direct oral anticoagulants in the treatment of venous thromboembolic disease.
Venous thromboembolic disease (VTD) is a frequent complication of pregnancy, with a significant risk of morbidity and mortality for the mother and her infant. Anticoagulation therapy is the primary treatment for VTD. Oral anticoagulation with vitamin K antagonists (VKAs) such as warfarin increases the risk of bleeding in patients, and the monitoring of the anticoagulant effect is burdensome. New direct oral anticoagulants (DOACs) were developed to overcome these limitations. DOACs (rivaroxaban, apixaban, dabigatran, and edoxaban) have several advantages compared to VKAs. Firstly, the monitoring of anticoagulation is not required, which allows for convenient, easy, and widespread use. Secondly, DOACs can be used in patients with a high risk of bleeding, such as those with a history of bleeding disorders or surgery. However, several studies have found that DOACs have a lower risk of major or clinically relevant nonmajor bleeding compared to VKAs. DOACs are widely used and have been shown to be superior to VKAs in the prevention of VTD in patients with a high risk of VTD. Recent studies suggest that DOACs are safe, although DOACs are less effective in the treatment of acute VTD than VKAs.As we have shown before, China is not willing to let the yuan appreciate against the dollar. If the U.S. currency does in fact depreciate against the yuan, that will of course mean a strong yuan becomes even more attractive to U.S. investors — for good reason.
The concept of a currency war is an interesting one. It has been particularly useful in keeping the perception of a U.S.-China currency standoff going. The evidence, to the contrary, is quickly becoming overwhelming. In fact, the reality is quite the opposite of what most traders have believed. The dollar is behaving in a fashion that will continue the role of dollar reserve currency and help make China a bit less attractive to U.S. investors.
At the beginning of the
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