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We examined human primary motor cortex (M1) in a large sample of subjects ranging in age from 5 to 73 years. These subjects underwent a functional MRI study that allowed the direct mapping of specific brain areas involved in motor performance. Voxels were identified in M1 that were activated by different patterns of finger movement. We found that M1 shows an age-dependent transition from a set of functionally defined units (motor representations) to two large and functionally distinct clusters located in the anterior and posterior portions of the ventral bank of the precentral gyrus (ventral primary motor cortex, VA, and dorsal primary motor cortex, VD). This transition is associated with the functional reorganization of the motor network. This gradual reshaping of the motor network in old age may explain some of the plastic changes that take place in motor function and contribute to the decline of motor performance that typically occurs in aging.Antiproliferative effects of treatment of classical Hodgkin’s lymphoma with nitrofurantoin.
Nitrofurantoin has been reported to be active against Hodgkin’s disease with a poor tolerance in some patients. The aim of this study was to evaluate the growth inhibitory effects of nitrofurantoin on classical Hodgkin’s lymphoma cell lines. The in vitro effect of nitrofurantoin was evaluated on Hodgkin’s lymphoma cell lines using cell proliferation, apoptosis and intracellular adenos
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