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Run the editor and select file. Select “Create from scratch” and follow the steps until you have the template loaded. Go to the menu and select “Design” > “3D” > “SketchUp Create”. Select the new shape you want to insert the template into. Enter the name of the template and choose whether you want to import the template. Select the image. Edit the parameters in the new window. References Category:Autodesk Category:3D graphics software Category:IOS software Category:Windows graphics-related software Category:3D modeling software for Linux Category:3D modeling software for MacOS Category:3D modeling software for WindowsThrombin-induced tyrosine phosphorylation and activation of adenylate cyclase in platelets: implications for signal transduction in human platelets. Thrombin is a potent activator of adenylate cyclase (AC) in human platelets. Although it is known that the platelet Ca2+ mobilization induced by thrombin is essential for AC activation, the mechanism by which thrombin increases the level of cAMP in platelets has not been defined. In the present study, we investigated the possibility that thrombin stimulates tyrosine phosphorylation and subsequent activation of AC via a direct action on the G-protein-coupled thrombin receptor, protease-activated receptor-1 (PAR-1). Tyrosine phosphorylation and activation of AC were observed in thrombin-stimulated platelets and were accompanied by increases in [Ca2+]i. Both the thrombin-induced tyrosine phosphorylation and AC activation were greatly inhibited by PP2, a Src family kinase inhibitor. These data suggested that PAR-1 activation in thrombin-stimulated platelets resulted in Src family kinase activation, phosphorylation of tyrosine residues on platelet proteins, and activation of AC. These results are the first to show that thrombin stimulates tyrosine phosphorylation and activation of AC in platelets. o f z ? F a l s e L e t t = 4 5 + — 1 6 .

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